I've been on HRT (gel and Utrogestan) for almost 4 months. It took a while to work and I had to adjust doses but the last few days, after switching to 200mg Utro in pessary format, I have experienced horrendous stabbing pains in my left breast. I do have a double fibroid in that breast that I understand can be reactive to hormones. I have seen my GP and she has referred me to the breast clinic but I am sure the pain has been brought on by HRT making the fibroids enlarge. Has anybody any knowledge of this or experience of this happening?