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[Sleepy123]

Good morning ladies! Hope you are all well !!
I have been using sandrena gel for about 6 weeks and feeling much so much better!
Although I am averaging about 6 hours sleep and I feel like it's not enough. I'm waiting for a Mirena coil to be fitted, so I'm hoping the progesterone will help me sleep better?

[Sleepy123]

Thanks Birdy! Fingers crossed it will be the final piece in the puzzle!

[Hurdity]

Hi Sleepy123 - I'm not sure whether the progestogen in the Mirena has an equally sedative effect as the natural progesterone that is in Utrogestan? Hopefully it will though!

What progestogen are you using in the meantime?

Hurdity x

[Mogster71]

Following this!
First night of progesterone, took at 7pm so I could have a snack before bed. I'm yawning like mad haha x

[Perinowpost]

Hi Sleepy123

I've found all progesterone to have a sedative effect, that includes levonorgestrel in the mirena x

[Mogster71]

Well it definitely had a sedative effect on me, I felt like I'd been elephant-darted last night.

This morning I am feeling pretty woolly. Does it get better over time? (2 x utro by the way). I might have to use it the other way if not 

[Sammiejane]

interesting that the mirena gives a sedative effect as this is obsorbed locally into the uterus and not systemically unless of course it is obsorbed systemically ? plus the dose is only 20mg whereby utrogestan is 100mg although only 20% is obsorbed into the blood stream

[Hurdity]

Yes sammiejane the progestogen in the Mirena is absorbed systemically - just not as much as with contraecptive pills containing an oral dose of the same progestogen. Not sure where you got those figures sammiejane - but you can't compare doses of different progestogens as they behave differently...

Perinowpost - that's interesting...

Ditto stellajane!!! I always hate the cycle when I have to take the prog ( always taken it vaginally) and it always has a sedative effect - I feel like a zombie. Hence the longer cycle. I'm always glad to stop. I don't find it has ever got better over time. I do become accustomed to how I feel on it but once it has cleared by system and the bleed has gone - I feel rejuvenated and full of energy ( except in the mornings  ).

Hurdity x

[Foxylady]

That is one thing I haven't tried, taking progyna before bedtime. I will give it a go tomorrow & see how I get on. Would be great if it affected me like you Mogster71. Although generally my issue is staying asleep not actually falling asleep! x

[Sammiejane]

hurdity

the dose of the mirena is 20 mg

the dose of utrogestan is 100mg however by the time is goes through the gut and liver only 20 percent is obsorbed by the body as progesterone.

i was told by gynecology the mirena isn't obsorbed systemically only tiny amounts not detectable in bloods hence why they suggest it as contraception for those who don't tolerate progesterone and again for hrt this is what meno and gyno told me it's obsorbed locally into the uterus to protect the endometrial however there is conflicting information out there even if that between gps and specialist with the majority not knowing there arse from there elbow

[Hurdity]

Sammiejane

Whatever your gynae said he was talking anecdotally rather than scientifically. Most docs will say that about the Mirena because it is in comparison with the contraceptive pill like I said - so in comparison it is minute. THis is the reason it is used for contraception yes. Nevertheless it most definitely is absorbed systemically and I quoted the actual amounts in a post on here if you are interested in the figures? Yes it is detectable in bloods  - because that's how they determine the effectiveness of the Mirena and how much progestogen it gives off over time. This is not conflicting information - it is established. Any medic who says otherwise is wrong - but like I said the docs will express a view on something in a different manner to a patient than if discussing the science with another medic or scientist.

Secondly - the Mirena releases 20 micrograms of progestogen per day initially which gradually reduces over the life of the coil. 100 mg (Utrogestan) = 100,000 micrograms of progesterone. 1 mg = 1000 mcg.

Also as I said the amount of the progestogen in the Mirena is not comparable with that in Utrogestan because they are different progestogens. Mirena contains levonorgestrel and Utrogestan is micronised progesterone. They work at different strengths to protect the uterus.

I hope this helps your understanding.

Hurdity x

PS Sorry Sleepy hope you don't mind this interjection here!

[Perinowpost]

As someone who had a mirena and had to have it removed it most definitely IS absorbed systematically. I couldn't tolerate it at all. In fact the only good thing about it was it improved sleep x