Of course it's relevant bear! Kilted cupid asked a question specifically about crinone as part of hRt and have posted the information that I have found re the research and its availability. The 4% has not been available since not long after I first came across it on this forum - probably more than 8 years but the study was quoted in the recent review of progestogens and their effect on the endometrium so the menopause academics seem to think it's relevant. Like I said the dose concentration in the research is lower than currently available but this makes it all the more interesting because lower doses appear to be effective in that particular trial so may not be associated with quite the same side effects. Like I said with the 8 % you would get more of a hit but still worth investigating as kilted cupid seems to want to try?
Kilted cupid? is the information I have provided helpful to your quest? re the generics issue - I posted about this recently ref Jeremy Corbyn's proposal at labout Party conference - and posted elsewhere about this the other day - briefly!
Hurdity x
Hi there,
I've read your posts and I'm aware you have found the research, but I don't think it's relevant to discuss a presentation that's no longer manufactured. If KiltedCupid's GP or specialist agrees to prescribe it off-licence (I hope you agree with the term), s/he will prescribe the only available presentation, 8%. Menopause academics might think it's relevant, but I was referring to KiltedCupid's more urgent needs (her FemSeven patches are about to run out).
BeaR.
Only just seen this. Because reference was made on another thread by kilted Cupid about potentially trying Crinone this point is actually important so at the risk of repeating myself ( !) – I disagree that the research is not relevant. Of course it is! See my comment above which well explains why! It is the only research into the use of Crinone as part of HRT and as such has direct relevance.
In terms of alternative progesterone, I'm going to ask my gp for Lutigest or Crinone gel if she can't give me utro and I'll post her reply so other members can be updated. I've only just started a new utro regime as my preferred hrt is no longer available, I'm not happy about that but once again, what can I do? I just have to pick my way through as best I can.
To explain further, the main criteria by which a progestogen is judged suitable for HRT (as opposed to luteal support in pregnancy) is its effect on the endometrium and specifically protecting it from over-stimulation by oestrogen.
In this case yes the dose concentration is different from that currently available but the crucial point here is that the dose tested was HALF THE STRENGTH of the current formulation and therefore if half the strength is effective (at the various dosages of Crinone and oestrogen studied) in these preliminary studies, then double the concentration will be too, although some guess work re dosage is needed – ie slightly less will be needed.
If it were the other way round you might have a point although the degree to which progestogens protect the endometrium is dose and duration dependent (as well as dependent on the dose of oestrogen).
Interestingly while trying to search for studies using Lutigest as part of HRT I came across this from the Chelsea and Westminster clinic – which mentions Lutigest but not Crinone as off-licence (off-label?) alternative progesterone preparations for HRT so for anyone who is interested in trying it - they are already recommending it.
https://www.chelwest.nhs.uk/services/womens-health-services/gynaecology-services/menopause-and-pms-clinics/links/copy_of_GPPrescribingAlternativesDISCHARGEPLAN.pdfI am surprised at the dosage being the same as utrogestan though because in terms of luteal support the amount of utrogestan is double that of Lutigest and by the same token one might decide that half the amount of Lutigest might be needed to protect the endometrium than utrogestan ie 100 mg for 12 days per 28 day cycle and alternate day 100 mg for conti use. Wihtout trials I imagine they are erring on the sdie of caution or using anecdotal observations from having already prescirbed it to women as part of hRT.
Hope this is helpful
Hurdity x
Author
Topic: Lutigest Progesterone Review (Read 9033 times)