Thanks so much for these replies. I have a history of reacting to very small amounts of drugs so hearing other people have experienced the same is helpful. I have taken the patch down by one eighth, cur the quarter I have gone up by in half so will see how I go. On a side note I went up quickly by a quarter before from half to three quarters, then I just experienced much worse short term memory so came down and went up when I had been on half a patch for longer and was ok. This increase also horribly impacted my memory so another sign it's the increase. As yet the depression hasn't kicked back in so fingers crossed.