Hello Beverley, I started on Evorel Sequi 3 years ago and had a range of side effects, palpitations, headache and sore boobs, but they all settled within weeks. I actually found the monthly bleed completely exhausting - for 24 hours each time I changed to the Evorel 50 I was physically drained like I'd run a marathon! You've had 3 years of menopause symptoms, if you can try to stick with the HRT to let everything adjust. Perhaps after 6 weeks on HRT you could write down what the advantages and disadvantages are and what the overall balance is for you? The great thing about the patches is that you can just stop using them, you are in control. Give yourself a little time to settle and recover and see where you are then?