Hi Anjia,
Yep same happened to me.
I was on EVOREL patch 50mcgs and had to switch to Estrogel.
I was fine on 2 pumps but when I upped to 3 pumps the anxiety was horrific! Through the roof! AND major depression too. It all happened within an hour of adding the 3rd pump.
I stuck with it for a week ( how I don't know) but then threw the towel in and dropped back to 2 pumps.
I think with the delivery method being different how we absorb and react differs too.
Try staying on your 1 pump for a bit longer before increasing to 2 pumps.
The increases need to be MUCH SLOWER for some.