SHBG - Sex Hormone Binding Globulins - are chemicals which the body produces to regulate the level of hormone available in the blood. If you have a very high level of SHBG it doesn't matter how much oestrogen or testosterone you put into your body, it won't be available for use because the SHBG had bound it up and made it inert. I think what's important is your serum hormone level, not the total level - the former is the available amount, the latter is the total amount. But I could be wrong about that - this is the sort of thing Hurdity is best at! What's annoying is that Gps seem to have no idea about SHBG and whether there's anything that can be done if you have a very high level. Sorry I can't be more helpful - I know there are things that will raise your SHBG and others that will lower it, hopefully someone with a bit more sense than me will come along soon and fill in the gaps!