Interesting, this is what I've noticed in the last couple of months and I've been on Evorel Sequi a year.
I'm better on the combined patches rather than the estradiol patches in the first half of the month. But while the discomfort is in the usual places where I would get it, it's got a slightly different quality to it in the last couple of months. The area on the right side that usually has a bit of discomfort is more intense, and the left side that doesn't usually get any has got some, so it's enhanced what was there usually.
If this is something to get through and come out the other side it would be good, but not sure I'd want to keep putting my body through this otherwise. Its not really painful but it's a reminder that my breast tissue isn't entirely happy and that's disconcerting. Otherwise I've been really well on Evorel Sequi.