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Author Topic: Utrogestan questions  (Read 1103 times)

sheila99

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Utrogestan questions
« on: October 18, 2018, 04:29:07 PM »

I am in peri and am on oestrogel and 200mg utro 12 days per cycle. I have the soft 200mg vaginal only capsules that aren't normally prescribed for HRT (gp didn't know). I feel fine except for the first 8 day on utro when I am really tired. I thought utro was body identical. Is it? Assuming it is - I didn't get this fatigue when it my own body producing it, so it must be due to either too big a hit when I start using it, or too high a dose.
1. If you have had both the vaginal capsules and the usual 2x100mg pills used vaginally - did you notice any difference between them?
2. If you've tried taking 1x100mg at 12 hour intervals instead of 2X100 daily - did it make any difference?
3. Has anyone tried a lower dose on a sequi cycle and tested lining thickness instead? Was it OK or was it thickened?
 I would like to understand why I feel so bad, and why the fatigue improves after 8 days.
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sheila99

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Re: Utrogestan questions
« Reply #1 on: October 19, 2018, 09:13:58 PM »

I think I've worked it out. Day 11 and I have started bleeding. I think my body is producing a lot of prog and with the added 200mg it's too much. Hopefully it will get better as I head towards meno.
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Hurdity

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Re: Utrogestan questions
« Reply #2 on: October 23, 2018, 07:03:47 PM »

Hi sheila99

You didn't get a response here but however....yes it is body identical but the reason many women react to it when taken (exogenously) as part of HRT as opposed to their own (endogenous) ovarian production is that the ovaries pump it out steadily and slowly at the amount needed and gradually builds up to the maximum whereas with HRT you have to take it all at once once a day. It is broken down very quickly in the body so you have to take it in large enough quantities to ensure there is always enough to get to where it is needed ie the uterus. Taken vaginally although it is more effective at protecting the uterus lining, women actually achieve (on average) a higher systemic (ie blood serum) level than when taken orally when much gets lost to digestion and metabolism by the liver.

I used to use the 200 mg capsules when they were produced for HRT ( exactly the same as the infertility vag ones!) and when I changed to the 100 mg ones I haven't noticed much of a difference - although, as I am on a 6-8 week cycle I can never remember exactly and also my response to the stuff does seem to vary - I have no idea why - but I think others find this too - just like with any HRT. After all we are not machines working exactly the same all the time...

I never split the doses - I would worry about the tiny balls falling out - after all there is nothing to keep them in place unlike vagifem and if you had a few children - well you're not excatly tight up there  ::) .

In a way I do take a lower dose on a sequi cycle- because I take the same amount vaginally (200 mg x 12 days) which is normal for a 4 week cycle when taken orally - because there is research (somewhere!) which showed you could take on average half the amount vaginally to give the same effect as an oral dose ie 200 mg orally = 100 mg vaginally - on average - this may not be exactly like this for you! This must be done under medical supervision though to monitor the womb lining. Mine has been thickened but I think that is because of the timing of the scan - my last scan was 10 days after start of bleed and was 7. something - if I'd had it done a few days earlier - the best time - it would have been better and would have shown if the utro was doing its job.

My (NHS) GP gives me norethisterone every now and again (supposedly once a year) to "strip" the lining just in case. I haven't taken this for a few years but will try to do so next cycle!

Bleeding on Day 11? Either your lining has thickened or as you say because you are in peri you ovulated at a different time so had an early bleed and you are producing a lot of prog too.

Hope this helps and it sorts itself out!

Hurdity x
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sheila99

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Re: Utrogestan questions
« Reply #3 on: October 23, 2018, 08:43:08 PM »

Thanks for your reply Hurdity. I'd forgotten I take it at night is so it stays in! What form does the norethisterone come in? I am on a 6 week cycle because I have a long natural cycle. I was assuming as long as I have a proper bleed each cycle all the lining would come away, presumably it's done it that way for the last 40 years. Do you know if this is the case? Just wondering if I should ask for norethisterone too, I wasn't aware this was an option. Isn't this the prog that's in everel conti? GP doesn't know I have a longer cycle, she isn't very clued up on meno.
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Hurdity

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Re: Utrogestan questions
« Reply #4 on: October 24, 2018, 07:17:01 PM »

Norethisterone comes as tablets - that is my only product I have taken oraly - I think I've managed to do it twice (ie for two cycles) over the past few years!!

The lining doesn't necessarily all come away but if you have no abnormal bleeding then no need to worry except for peace of mind if you (with your doc) are following a non-standard prog cycle?

Not sure that it is an option - just something my GP suggested when she said it was OK to do long cycle HRT. Yes it is same as in Evorel conti. I didn't tolerate it with those patches ( years ago) but seemed to be more or less OK with a course of tablets. It did weird things to my blood sugar (a bit of extreme reactive hypoglycaemia that I am prone to) but apart from that I was suprised I coped with it. I am prepared to do it once in a while if it means I can stay on long cycle HRT for the rest of the time - at my age ( mid 60's).

I don't go to my normal GP for meno but we are v lucky to have a part-time gynae specialist GP who is my age but carries on working and has specialised in all things gynae for all the time I've been there - over 30 years! She studied with John Studd many years ago so knows about progesterone....

Maybe tell your GP what you are doing and what you want? Educate her? I know some are not open to this though....

Hurdity x
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sheila99

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Re: Utrogestan questions
« Reply #5 on: October 25, 2018, 09:25:29 PM »

I haven't found anyone who can advise what you should do if you have a long natural cycle. I seem to do better with my normal cycle length, the 28 day cycle resulted in erratic bleeding. I'll tell the GP next time I see her, perhaps she'll agree to scan after a year. I haven't had any abnormal bleeding since going on the longer cycle (only 3) except for the most recent bleed starting before utro finished.
 
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