Not sure if this will help, but I'm using Androfem now and it comes in a tube like toothpaste. The instructions are to take the top off, squeeze gently until the cream appears at the opening (i.e. no airlocks), insert the syringe into the nozzle of the tube, turn the tube upside down so gravity helps and put the syringe down to fill. I use .5 and over fill a little and then push it back into the tube to ensure no air bubbles.
It depends if the opening to your bottle could behave in the same way I suppose.