BeaR - thanks for the info, really interesting. Just to clarify, it's the Crinone which ladies found most comfortable to use and with least side effects? Do you know if it's available, even off licence, for hrt use?
Hi KiltedCupid,
CRINONE ® was produced by Juniper Pharma Services, a former UK company which was developing an intravaginal ring with bio-identical progesterone and bio-identical estradiol for HRT.
https://seekingalpha.com/filing/3930569Page 9 under Hormone Replacement Therapy.
‘Our Solution – JNP-0201
We believe that JNP-0201, our combination estrogen and progesterone IVR product candidate, has the potential to offer patients multiple benefits as compared with currently available therapies, including: integrated administration of natural progesterone and natural estrogen; improved patient compliance; improved side effect profile; and continuous local vaginal delivery of natural hormones, while eliminating the need for daily administration.'
Unfortunately Juniper has been acquired by Catalent in July 2018. 'Catalent will continue to support Juniper's CRINONE® (progesterone gel) franchise marketed by Merck KGaA outside of the U.S. Juniper's Intravaginal Ring development pipeline was previously licensed to Daré Bioscience, and Catalent will not be involved in the further development of this program.'
Fortunately, Daré Bioscience seems to be initiating DARE-HRTI (Intra Vaginal Ring, combination bio-identical estradiol + bio-identical progesterone) phase 1 this year in Australia.
https://darebioscience.com/pipeline/Let's hope they succeed!
BeaR.
PS. Yes, according to that study, the subjects found Crinone was the most comfortable and yes, I think it's available off licence for HRT, but it's very expensive and the dose (90mg) is not significantly different from Utrogestan (100mg), but it might suit those women who have intolerance to Utrogestan's inactive ingredients (sunflower oil and soya lecithin).