Hi Sue. I can relate to this. I'm post meno and still trying to find a HRT that I'm totally happy with so very up and down at the moment. I think my down times are because I feel so rough sometimes and find it hard to keep positive when there doesn't seem to be a light at the end of the tunnel. So it's a bit of a vicious circle i.e. when I'm feeling ok healthwise my mood is lifted and when I'm feeling rubbish I feel down - very much can't be bothered with myself like putting on jewellery, make-up, perfume etc which is so unlike me.
I'm not an expert at all at the science of HRT but I'm thinking that once you are able to tweak your HRT you will start to see an improvement. I'm lucky in a way that I don't work anymore because I think I would have had to pack it all in anyway because of the way I've felt over the last 8/9 months so I do feel for those ladies on here that are still trying to deal with meno symptoms and do a days work. As you can see from the responses to your post, Sue, you are definitely not alone in how you are feeling and there will be loads of support for you from the lovely ladies on this forum so try too keep your pecker up :-)
Wishing you well !
Rosie63 x