Hereandthere - I think many of us have found our tolerance to alchohol and the way we metabolise it has changed as we have got older and not necessarily on account of HRT. For me it wasnt so much nausea as migraines - even after only two glasses - if I drank it later in the evening. I first noticed it even when still having regular periods - probaby late reproductive stage. When I started HRT it got worse but I think it would be anyway at my age - now in 60's. I haven't been able to drink that much wine like you mention, since my early 30's!! Five glasses is a lot and especially if not small glasses!
Now I have worked out how much alcohol and when I can drink it without feeling ill/getting a migraine. I only drink it early in the evening (or earlier in the day eg over Christmas!) and with food, and drink at least a large glass of water for every glass of wine and in between the first and second glass for example. Probably would have no more than eg a G & T before the meal and a couple of glasses with food and finishing no later than 9 pm. Always loads of water before bed. ie I go to bed after all the effects have worn off (very boring I know - but the only way I can still have a little drink or two now and again). I limit it mostly to weekends Fri - Sun ( except I'm doing dry Jan - even more boring!).
I also used to feel worse with alcohol when on the prog part of HRT ( even though I don't take any HRT orally) and on the prog withdrawal weekend.
I would say to anyone who would like to enjoy a little tipple - no need necessarily to give it up completely but try doing what I do.... and see if you feel OK?
Hurdity x