Witchy, Duavive has been around for quite some time now and we've had several discussions about it on here. Scotdownunder is using it and if I remember rightly, her specialist said it was OK for her to take it in peri menopause.
I would give it about 8 weeks before deciding whether or not it is for you.
I am severely progesterone intolerant and think it is important to try new HRT products as they come onto the market so I decided to trial the SERM part of Duavive (bazedoxifene) with two pumps of Oestrogel. In theory, it should not have worked with bioidentical oestrogen but it did and the SERM definitely switched off the breast and womb receptors and I didn't have any breakthrough bleeding at all. Unfortunately, I found that my sweating symptoms started to return so I had to ditch it. I didn't think the SERM would oppose the oestrogen and undermine it but unfortunately it did - again, this should not happen in theory.
When I stopped taking the bazedoxifene and went back to Oestrogel only I decided not to take Utrogestan again until I had breakthrough bleeding. It was a long time before I bled again and my periods have been lighter every since so that is a bonus. Of course I had a uterine scan after this experiment and all was OK.
I was going to trial Duavive proper but decided against it because the oestrogen dose would have been far too low for me - my gynaecologist didn't think it would work. That said, I think it is a interesting product with a lot of potential and I would not want to put anyone else off trying Duavive because it works well for many women and hopefully it will be available in different doses in the future.
I was going to start a new thread on my bazedoxifene/Oestrogel trial but I decided against it.
