Hi Mandylou
Heavens above what ignorant doctors!
OK so you were peri-menopausal two years ago - what was your cycle doing then ie did you miss many periods, were there long gaps between them?
As you have found yourself of course the HRT types are not all the same - some of them contain different oestrogens, different progestogens, some are tablets, some are patches, some are cyclical ( to give a withdrawal bleed) and some are continuouis combined (no-bleed).
First thing - Elleste Duet conti differs both in oestrogen and progestogen and is a continuous combined type so no wonder you feel different. I am assuming this the the 2 mg one (I think the 1 mg one has been discontinued)? Which dose of Prempak C - was it the 0.625? This contains a mix of horse oestrogens so different from all the other types which contain estradiol - bio-identical to the oestrogen in our own bodies, so better to have HRT containing this one really. I think the PRE horse oestrogens are being phased out as they are now old-fashioned.
Some women find that having continuous progestogens does not completely suppress hot flushes and anecdotally (from posts on here) norethisterone (the progestogen in Elleste Duet) seems to be the type that causes a greater resurgence of hot flushes.
If you are not post-menopausal then you should not be on a continuous combined HRT. Here are all the types for peri-menopause:
https://www.menopausematters.co.uk/perimeno.php but if you don't want a bleed - then how about a Mirena coil? This delivers progestogen directly to the uterus where it is needed and then you can add oestrogen as a patch or gel until your symptoms subside.
If you have Fibro and ME it may be the reduction in hormones causing the symptoms flare-up. Have you had these for long? Also have you had thyroid function checked. There is a link between hormones and all of these conditions women get diagnosed with in mid-life - fibro, ME, CFS and HRT at the right dose (or thyroxine if thyroid problems) can eliminate or control them.
Why not try the Tridestra and see what sort of bleed you get? However if you are not near menopause then it's pointless because you could get breakthrough bleeding before the 10 weeks is up - but maybe give it a try?
Hope this helps
CLKD I couldn't understand your post as it seemd to be a repeat of Mandylou's and I couldn't make out which bits were your responses - so I'm confused and didn't read it all through to try to work out which was new!
Hurdity x