After 12 weeks you certainly should be feeling some benefit if the AD is going to work; as the others have said, some work for some people and others for others, so you might have to try a few, but to be honest if you are menopausal your doctor should be considering hormonal treatments before automatically prescribing antidepressants - they just do it automatically, we are an invisible section of the population as far as most GPs are concerned. Low estrogen can certainly cause depression, and low testosterone can be a cause of anxiety. And as for progesterone, well that's a whole other ball game.If you're able to I'd ask for a referral to a menopause clinic/specialist where they actually know what they're doing.