Hi daisy - It you are starting from a very low oestrogen level (I assume you have had a hystestomy?), then the hit of oestrogen can give some side effects at first. This should settle and the 50 patches are a normal dose. Expect your breasts to get a bit tender and your ‘lady bits' may tingle - this is your body ‘waking up' and adjusting to the hormones.
Try eating small amounts often, avoid caffeine and drink enough water. It will get better but if in a few weeks things aren't improving, you may wish to change to Oestrogel as this is applied daily, you have more control over dosage and this can be more consistent. DG x