Hi racjen When I think back to the sertraline I started at 50mg and it was awful dry mouth, constapation as you describe and even more suicidal thoughts, unbelievable when it is supposed to be to help you. Non of them work fast. I used to increase in 2 week intervals if nothing was changing, 75 mg, 100mg, this was about the 6 week stage when the descructions say they should start working but again we are all different.
I started having the odd good day which I wrote down so I could remember because depression would like you to think you have NEVER been happy oh yes you have. Still wasnt good enough so 2 weeks later 150mg, having more "good days" but bad days would follow which can be even harder as you almost think you are back its like it teases you.
At around 10 weeks in and im now on 200mg it all started to come together.
I was running each day and each day when I was ill I would look at the canal and think I could just jump in and it would all be over. I would come home shower and then cry for most of the day.
Once I was on 200mg, it took about a week and it was like a light had gone on. I went for my run and I looked at the canal and I thought never would I jump in there in looks cold and dirty. I since found out it would have only come up to my knees anyway. That's when I knew I was well as my self preservation had kicked in.
I came home for my shower and for the first time in almost 12 weeks I put the radio on and enjoyed listening to the music again. That's when I knew the levels were in the right place. It is so easy to give up on anti depressants and I know why because they can make you feel even worse at the beginning than you were feeling, there arent many medications that are so cruel. Trouble is they have to get into the brain and thats all complex stuff and it takes time and also depends on how low your serotonin has gotten.
Basically they saved my life and nothing was getting me better, all the st johns wort, acupuncture, loads of exercise, all the alternative stuff, nothing I needed proper meds to get the balance right. I would still be on it if it hadnt stopped working due to me having no oestrogen. i asked about long term side effects and my dr said only brittle bones but if you do exercise then you will be fine.
Hope that helps a little, keep going it will all be alright in the end. xx