Yes, for me depression and anxiety have been my main symptoms - I did have hot flushes before I started HRT but they weren't too bothersome. So far adding estrogen has definitely helped with the low mood, but progesterone is causing more problems than it's solving. It seems that mood problems need a much higher level of estrogen to resolve than the physical symptoms - my hot flushes disappeared within days of starting HRT. Dont know if you're already on HRT, but don't let your GP fob you off with 'there's no evidence that depression/anxiety are linked to menopause' as mine tried to, you only have to browse this forum to see that they most definitely are!