Hi Hurdity, as luck would have it I had a follow-up appointment booked with Dr. Gray in Plymouth yesterday. Arrived at her office a complete blubbering mess after realising half-way there I'd left my bag with money, cheque book etc. at home. She was brilliant - said it looks like I'm severely progesterone intolerant and that that would probably have been made worse by very low estrogen levels. She's upped my Evorel to 150 and also prescribed a very low dose of amitryptyline, which kind of resets the brain chemistry after the progesterone has messed it up (causing the really acute anxiety). This morning I already feel loads better, and relieved because I really didn't want to have to resort to diazepam, I became dependent on it when I had a perimenopausal episode like this 6 years ago - at that stage I had no idea what was behind it. So now giving the progesterone a break till after Christmas and trying not to think about what happens after that x