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[Mini1]

Firstly, I'm sorry for asking loads of questions but I am desperate to understand what is happening to me.

I've just started taking Kliovance.  Am I right in thinking that the oestrogen has to build up in your system and that's why it takes a while to see any effect? X

[CLKD]

Does it give any info in the leaflet with the product?

Maybe put the product name into the search box here to see what pops up?

Oestrogen levels rarely drop suddenly so what ever HRT is prescribed, it's unlikely to work immediately 

[Mini1]

Hi CLKD

Thanks for your reply.

I've read online that it takes a few weeks for the hot flushes to go. I read that in a leaflet about the drug.

My worse symptoms are nausea and exhaustion with severe hot flushes.

You say that oestrogen levels don't usually drop suddenly, so do you mean that the hrt tablets build the oestrogen back up gradually?

[CLKD]

I would think that HRT would gradually build up ......... do put the product into the search box on here for more info..

[Mini1]

Yes I have typed Kliovance into the search engine and read a lot of the posts.  A lot of them are giving quite negative reviews, which I don't really want to read just now. 

I know I've got to be patient but its hard to be patient when I feel really ill xx

[CLKD]

Of course it is.  Maybe keep a food/mood/symptom diary?

[Taz2]

Hi Mini1. Although it is difficult to be patient it can take a few attempts to find the best HRT for you. Patch and gel types of HRT tend to work faster, especially on relieving hot flushes, as these are absorbed straight into the bloodstream. It can take a few weeks for pill HRT to achieve the same effect. If you are suffering from nausea then a patch/gel type of hrt may be better for you as they have less digestive issues. Different progesterones affect women in different ways so, if this is the case then trying other HRTs may help,

The advice is to try each HRT for three months as it can take this long for things to settle down and the full effect to be felt.

Taz x

[Mini1]

Hi Taz thanks for your reply.

The nausea started before I started the HRT and is a symptom of the menopause I think. I'm hoping that once my oestrogen levels have risen then the nausea will stop.

I know I've got to be patient....

[Taz2]

I just wondered that if you were already suffering from nausea then maybe a patch or gel HRT would be kinder for you? I used Kliovance for a while. It did give me morning nausea but that passed after a couple of months. Nausea was not part of my meno symptoms though. Do you feel sick all day or at specific times?

Taz x

[Hurdity]

Re how does HRT work - it is a very complex thing - not sure if it's even fully understood yet...Oestrogen is responsible for and affects many functions in our body and there are oestrogen receptors everywhere - also several different types of oestrogen receptor too. It has different effects in different parts of the body where the receptors are (known as target tissues) - or known as tissue specific effects.

The interesting thing about it is that oestrogen levels do rise and fall suddenly - in the menstrual cycle and the effects of this are felt immediately. This is because there are oestrogen receptors on some cell-membranes (so this is one level of operation) - we are all familiar with feeling great aorund ovulation and lousy just before our period. Some women can feel the rise in oestrogen following menstruation or two or three days in - I certainly used to. it is the rapid changes in oestrogen that give rise to PMDD or extreme pms ( progesterone also plays a part).

The other main effects of oestrogen are through the cell nucleus and are called genomic effects - these are the long-term ones eg skin, bones etc. Various proteins are activated and give rise to the changes. It all involves very complex cell biochemistry which only the real specialists who study and write papers about it know about in any depth! I certainly don't - only to know that it works on two levels due to the location and action of oestrogen receptors.

That's probably not the answer you were looking for and Taz's is much more practical!!! As she says- transdermal HRT is preferred for those who have digestive problems or nausea with tabs....

In terms of the Q you were asking CLKD - replacement HRT can also work in both ways - short-term - pretty immediate feelings of well-being, and long-term. Vaso-motor symptoms - seems to work pretty quickly in mosrt women. Most of its benefits are long term - it needs to bind to the receptors in the cell nuclei, and get all the cells busy doing their stuff.....so yes it does need to build up - or rather the effects do....if you see what I mean? Is that too rambly! Sorry if so 

Hurdity  x

[Taz2]

That's probably not the answer you were looking for and Taz's is much more practical!!! As she says- transdermal HRT is preferred for those who have digestive problems or nausea with tabs...

Hurdity  x
[/quote/]

Mine might be practical but your advice is really interesting and put in a way that I can sort of understand 

Taz x

[Mini1]

Thanks for all the super replies.

Taz- I feel sick all day and have done for about 3 weeks. It's not nice as I don't want to eat x

[CLKD]

Oh I remember that nausea so well.  Products with ginger in may ease symptoms.  Also eating little and often so that the gut doesn't become empty, difficult - I'm a recovering anorexic  - I graze on dried fruits and nuts, bananas which can be nibbled - pancakes are my main-stay or chicken curry in order to keep my body fuelled.  My trick is to remember to eat B4 my body is hungry!

[Mini1]

CLKD - I don't feel happy hungry and have to force myself to eat. Did HRT stop the nausea?

[Taz2]

Do you have anxiety? This can give you nausea. As I mentioned earlier tablet HRT may not be the best option if you are suffering from nausea. A patch or gel HRT is much kinder.

Taz x