Thanks Roseneath. I am beside myself today. I have an appointment with the GP later and I'm going to see what he comes up with. So far he's been great and I've certainly had a much better experience that a lot of ladies seem to have done. I can't take the Duet, I'm turning into a mad woman! My poor husband is taking a kicking on an hourly basis, I think he's glad to be at work. My anxiety levels are off the scale, I'm having suicidal thoughts and when I'm not doing those things I'm sitting in the corner crying. This stuff is evil. Tbh, if I can't change to something better I might as well not be on it. Just can't believe how different two meds can be. I started with40mg of propranolol when I first started on hrt to calm me down until the hrt had an effect, so I might ask if he can let have some again so I can at least enjoy my hols. 🌴🌞