Bless your heart, Annie! You know how I like to post studies to prove my little theories........
![Wink ;)](https://www.menopausematters.co.uk/forum/Smileys/extended/wink.gif)
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Yes, Edelweiss! My levels were miniscule WITH transdermal estrogen and the best guess from my Consultant was that I simply either wasn't absorbing or perhaps I was, and the estradiol wasn't circulating. I felt about the same physically on Premarin and Tibolone too - but in fairness, the doses were small (Tibolone is weakly estrogenic). Of course, neither of these can be measured in the blood.
I know over time that the estrogen receptors down regulate in the absence of stimulation from hormone - I feel I'm 'dicing with it' here at the moment as i'm not on any HRT and have been off now over 2 months. My Endocrinologist is keen for me to start again, but goodness knows with what! Thus I'm waiting to see Professor Lumsden at her Menopause Clinic in just over a week.
Can I ask which preparations you've used Edelweiss, and if you're still using HRT now despite having no response from it? Implants are still on offer at my Menopause Clinic, but I'm scared to go there without knowing what level I would feel comfortable at!
CLKD - absolutely!!!!! Early trauma and prolonged life time stress has been proven to predispose to autoimmune disease particularly, as well as cardiovascular disease, diabetes and overall early mortality. Not a pretty picture, is it?
![Cry :'(](https://www.menopausematters.co.uk/forum/Smileys/extended/cry.gif)