For six years now I have been experiencing very bad bladder problems (sensory urgency). I have tried everything - topical HRT, long term antibiotics, urethral stretch, bladder investigations, instills, etc to calm it down and get back to how I was before this nightmare began. For the last four months I have been on nightly topical HRT using ovestin, vagifem (which burned) and this week Estring as my research showed that it can help chronic bladder symptoms linked to the menopause. My bladder symptoms for the last four weeks have gone through the roof with constant feelings of a full bladder even when I have just gone. I leave it until I really need to go with the hope that the feeling won't come back, but it does. I have been using Multigyn to try and calm down the soreness and burning I feel from time to time which I thought might be BV as got diagnosed with anaerobic bacteria in January and was prescribed Metronizadole. I took that then took Coamoxiclav directly afterwards after having visited the gp for the ongoing chronic uti symptoms although dipstick was negative. I then took a few Fluconazole. Visited gp last week but urine sample was negative with the dipstick. He did not send it off for culture. Most nights I sleep through although I do wake up about 4am or 5am then once awake my bladder symptoms rule till I then go to sleep at night. I have a white discharge but it does not look like thrush as I have had that in the past. I really can't go on like this as I am becoming housebound and can't function. Symptoms remain really bad with discomfort in urethral area more than anywhere else and I am at my wits end.......