Hi Whitterz67
Phew - you've been through a lot.
If you had not been period free for 12 months before starting HRT then you were not yet at menopause - well you might have been - but you don't know this until 12 months period free so if you start HRT you never know and just assume at age 54 or before if you started peri-menopause very early, that you are post. Usually women who start HRT before the 12 months period free has elapsed, are put on cyclical HRT which gives a regular bleed. Because you were not put on this but on continuous combined HRT, it could explain why your womb lining has thickened although puzzling you have not experienced any breakthrough bleeding.
If you were given anti-depressants at the same time as starting HRT ie for hormonal depression that is new to you and not due to life events - this is no longer advised as per the NICE Guidelines. A hormonal solution only is recommended - and sometimes a few attempts at different types are needed before settling on the right one. Only after all these have been tried and at different doses should ADs be considered - really as a last resort. Also continuous progestogens can lead to depressive side effects in some women so it may well have been a change in progestogen you needed rather than increased ADs - ie medication to alleviate the wrong medication (the progestogens in Premique). Just a thought.
It may well be that your oestrogen levels are too low as has been suggested, and I agree a different type of oestrogen may well be beneficial and make you feel better. Some women do not respond well to the equine (horse) oestrogens you are taking.
I agree a Mirena with oestrogen patch or gel may well be the way to go - you are still young to be on a low-ish oestrogen dose.
By the way I'm not up with these abbreviations - PMI? TRX? I do know HRT, SSRI, CBT, IBS, OTT, GA,and GP though
Hurdity x