Michelle46, as long as I don't take too much of it, I don't suffer from any side effects when using it vaginally. It does make me sleep very soundly, not that I have any trouble sleeping, but I don't get any breast pain because most of it is localised and goes where it is supposed to i.e. the womb. However, if I take it for too long, it eventually creeps into my overall system and can cause migraines and low mood. Therefore, I never take it for more than 7 days and stretch the cycle to 5 weeks and I can just about live with that!