Hi, has anyone had a delayed reaction to oestrogel? I have some intolerances to certain chemicals in toiletries & have developed allergies to two groups of antibiotics over recent years along with food intolerances. Just recently, I had an extreme flushing reaction to a drink on holiday (it looked like bad sunburn)so I am unsure whether this sort of thing is worsening. Recently I started oestrogel and, within a couple of days, noticed a couple of bumps on my face but thought that maybe it was due to eating a piece of chocolate. My cheeks also appeared to be flushed. This normally occurs if I eat the 'wrong' foods. However, this has rapidly worsened with many more appearing on my back with a few odd ones on the rest of my body and itching and tingling all over. In the meantime, my eyes are getting drier, itchy & sore with my vision being affected. The itching starts off milder and worsens as the day wears on (last night it was unbearable). I apply the gel in the morning. As these symptoms are identical to what I had when I developed the intolerances, I am concerned. I had to stop taking my old antidepressants because of this (my eyes were so sore that eye drops only gave brief relief). Other medicines that I have taken recently such as my vitamin pills have not caused this problem as I started them before the gel. Could the symptoms be worsening as the oestrogel builds up in my system? I know we are supposed to give hrt time to settle but does anyone think I should stop & wait until my appointment with the gynae GP eventually comes through & see what she says?