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[GypsyRoseLee]

I have taken it in the past and it tends to make me feel quite depressed. So I will try and do without it. If I only have to face this Hell once every three months I should be able to cope.

[walking the dog]

Yes I was /am meant to be on huge dose of progesterone daily but cant face it I'm bleeding terrible at minute now on two sanitary towels every half hour and my moods so low I just keep crying in sick of my life to be honest its got to the point where I dont care about the hyperplasia as my moods my bigger concern I can't carry on like this but I'm not getting any help to sort it out

[Tempest]

I second being careful with Diazepam. An occasional 2mg is probably ok, but I had 6mg over 12 hours in 2mg doses and had pretty severe confusion and short term memory loss for 2 days! I was told that it was unusual, but upon discussing it further with a psychiatric ward senior nurse I was warned that rebound anxiety if you use it regularly is a beast too (and yes, it can make you feel depressed).

[clare663]

Hi all.  I have just moved from continuous use of utrogestan to sequel (I'm 5 yrs meno and uses eastrogel) couldn't cope with the tiredness after 2 weeks on it.  I am 4 days into my 12 day use of utrogestan and have been in tears most of the morning.  I didn't experience this and such a low mood before.  I'm using 100mg virginally.  Any ideas?

[Lizab]

I have a theory about the ones who love the utrogestan. I suspect their estrogen  or testosterone still a little lower than ideal for them. The body can convert progesterone to the other hormones. When I was on 37.5 estrogen patches, my best days were on the utro. Now, on 50 estrogen, I have a rougher time on and following the utro. I'm thinking I was getting a little more estrogen from converting the progesterone and that was making me feel better during that phase. I thought about asking for continuous progesterone even though I'm not a year without periods, but boosting my estrogen seemed to give me the same positive outcome. I guess it all goes back to finding your own sweet spot to balance it all out.

[clare663]

Hi meno mate.  I took it for just over 2 weeks but was so tired it was effecting my work badly.  I have felt pretty good on the eastrogel but was still getting warm moments on 2 pumps when my flushes had gone on 2 pumps when I used the utrogestan continuously.  I can't stand feeling low and crying even though I no it is the hormones playing up! This is the 4th type of hrt I have tried and I just end up an emotional wreck on it!!

[Hurdity]

Yes I was /am meant to be on huge dose of progesterone daily but cant face it I'm bleeding terrible at minute now on two sanitary towels every half hour and my moods so low I just keep crying in sick of my life to be honest its got to the point where I dont care about the hyperplasia as my moods my bigger concern I can't carry on like this but I'm not getting any help to sort it out

Hi again walking the dog

As I said in my other post below - if you are needing a high dose of progesterone for a temporary period of time to thin the endometrium then it would be better to take one of the synthetic types, the reason being that much smaller doses are needed because the molecular formulation is more stable. Progesterone itself (as in utrogestan) breaks down very quickly in the body so larger doses have to be taken - especially orally - for sufficient to be absorbed. it is the large doses and the metabolic by products that cause most of the unpleasant sdie effects. When you have thinned the endometrium - you can then go back to a lower dose either every day ( the 100 mg) or the 200 mg cyclically - and vaginally you could probably just take it for 10-11 days.

Hurdity x

[GypsyRoseLee]

I think some women can tolerate progesterone if it's consistent in their system. I think what causes the havoc is 'changes' in the level of progesterone.

Last year when I was on a BCP continuously, I had a brief 4 day break from it (by accident) and it made me feel absolutely dreadful.

Then when I suddenly stopped Femoston 2/10 halfway through the combined tabs I had another horrific experience.

And now, even on high dose oestrogen I get wobbles when anything happens to change my hormone levels. So when I ovulate, or when I finish Utro, or when my own oestrogen starts to rise.

[Hurdity]

I'm taking it vaginally, so this "good" sedating effect is not happening to me, maybe it happens just via oral route.

The sedating effect can occur vaginally too - it does with me - but presumably not as  pronounced as with oral use (which I have never tried - I probably would find it even more difficult to wake up than I do already, every day!). Lucky for you that you don't experience this!

Hurdity x

[walking the dog]

Utrogestean seemed to suit me at first but as times went on it makes me feel suicidali dont get any of the relaxed sleep feeling people talk about I'm like a wound up screaming banshee on it ! Cant have mirena plus if could wouldn't want risk it as I'm now coninced I'm progesterone intolerant currently using estrogen without progesterone on my own decision until see menopause specialist in just over a week feel totally gutted hrt hasn't helped 😢

[Hurdity]

I have a theory about the ones who love the utrogestan. I suspect their estrogen  or testosterone still a little lower than ideal for them. The body can convert progesterone to the other hormones. When I was on 37.5 estrogen patches, my best days were on the utro. Now, on 50 estrogen, I have a rougher time on and following the utro. I'm thinking I was getting a little more estrogen from converting the progesterone and that was making me feel better during that phase. I thought about asking for continuous progesterone even though I'm not a year without periods, but boosting my estrogen seemed to give me the same positive outcome. I guess it all goes back to finding your own sweet spot to balance it all out.

I wasn't aware that progesterone is ever converted into estradiol or tesosterone. I know they're all on related pathways and derive from cholesterol but in practice does this ever happen? If this were the case we could all take progesterone only and be OK for oestrogen - which is not the case 

Hurdity x

[Hurdity]

I think some women can tolerate progesterone if it's consistent in their system. I think what causes the havoc is 'changes' in the level of progesterone.

Last year when I was on a BCP continuously, I had a brief 4 day break from it (by accident) and it made me feel absolutely dreadful.

Then when I suddenly stopped Femoston 2/10 halfway through the combined tabs I had another horrific experience.

And now, even on high dose oestrogen I get wobbles when anything happens to change my hormone levels. So when I ovulate, or when I finish Utro, or when my own oestrogen starts to rise.

Yes that's true GypsyRoseLee - most women feel the effects of progesterone withdrawal - after all this is classic pmt just before a period. Some women also react to the rapid rise ( but more often to the fall). However  those who react negatively to its presence (as well as changing levels) are progesterone intolerant to a greater or lesser extent. The others aren't - it is normal to feel the effects of the changes that occur as levels fall sharply - some do experience this more than others though.

Hurdity x

[clare663]

Hi menomale (apologies for spelling your name wrong last time). I tried a sequi tablet form (can't remember the name) when I was still in peri but it totally wrecked me within a week.  I left it until I was definitely meno and tried a continuous tablet (again I can't remember the name) but I bleed extremely heavily every month and was in agony and also the low mood got worse so I stopped after 6 months.  I had another break for 2 odd years then tried the evenol conti 50 patches.  Initially it was great but after 6 weeks I ended up suicidal.  As I said I started the continuous gel and utrogestan  but I was so tired I switched to the sequi.  I'm wondering if I upped my eastrogel whilst on the utrogestan it may help but then again!!!!

[andius]

Re progesterone converting to other hormones:

I think this may depend on where you are in peri or menopause and also what your individual baseline levels of hormones and enzymes are. Some people may be more sensitive than others.

Every time I have used either vaginal or sublingual progesterone (both avoid digestion and liver metabolism on first pass thru body), my total testosterone blood level goes up to highest normal range and sometimes higher and the free testosterone increases some also. It takes forever for it to go down (months). If I take it orally at 100mg, my testosterone level stays in mid to lower normal range for my age. I don't like it to be high because I don't like how it makes me feel, makes my bladder worse, and I get acne spots mostly on the buttock area. Taking it orally at 200mg causes testosterone to rise also, but not as much as vaginal or SL dose. I don't cycle so I use prog 25 days/mo.

So...I am a believer in this.  However, it has never shown to change my estrogen level appreciably...maybe because I am taking estrogen too via patch??     I am menopausal > 5 yrs.

A

[andius]

Higher testosterone made me testy and made my bladder burn a lot (prog was high at this time also, so could have been due to either or both). But I wasn't taking any testosterone....when prog dose was lowered, the test levels slowly went down.Muscle mass maybe a little better. Gained weight though. Libido I couldn't answer....VA and bladder pain was so bad at the time, no way I was thinking of sex....just trying to get through the day.

Never used prog gel....only prometrium vaginally was tried and sublingual compounded progesterone troches.

No idea of current estrogen levels...my baseline is 5-7 pg/ml with no HRT....currently using 50 patch and it works for me.

Haven't had any tests in last year or so since I finally found the dose that seems to handle my issues well that I can tolerate.