Anxiety is a menopausal symptom - I think flushes, night sweats, palpations and lack of sleep make anxiety far worse so oestrogen will improve things and having more energy will make most of us 'feel good'. I have found that too high a dose of oestrogen can make me feel agitated and wired so I think finding the right dosage is important. You may be one of the poor ladies that, for them, oestrogen is not enough and an SRRI alongside may be needed to really keep the anxiety under control. I assume you have looked at diet, exercise and some meditation to help with anxiety? HRT cannot fix everything - it is often necessary to include a range of measures to control the anxiety and low mood aspects of the meno. You could try stopping the oestrogen for 4-8 weeks to see if your anxiety improves - this would allow you the opportunity to really assess whether you need it or not? Perhaps try a lower or possibly a higher dose? If you use Oestrogel this would allow you to experiment a bit to find the right level. DG x