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[Chi chi]

This is interesting as I have bought some Serenity cream but have held off using it so far as am nervous about it.

Can I ask where you bought it from? I've seen it from Wellness, is this the correct place to get it?

[Annidav]

Hi I bought it on-line from the Wellsprings site

[Hurdity]

Chi Chi - do not buy this much hyped stuff! It's not supposed to be promoted on here anyway. It will not do what you want it to do. It is very weak and will not protect your uterus at all!!! This is a distraction. I appreciate your search for a progesterone that you can tolerate but your best bet is still utrogestan as being the most "natural" - in the same way that the cream is - but just a whole lot stronger and available on NHS. Any cream or product that is strong enough to protect your womb is likely to cause the same side effects as utrogestan - if you are susceptible.

Annidav - I don't know what you've bought it for but it's harmless.

Hurdity x

[dogdoc]

I'm with Hurdity. Intravaginal utrogestan did not affect my mood to the same extent as the topical compounded stuff ( still micronized progesterone).
And yes...it sounds like there is some basis for using progesterone ( Not necessarily transdermal) to regulate bleeding in early perimenopause particularly...just be aware that many women are sensitive to the mood effects of progesterone regardless of route.

To minimize side effects and maximize uterine protective benefits/reduce bleeding....i'd go with intravaginal utrogestan myself. but that's just me.

[Chi chi]

Thanks everyone, I haven't bought any, just clutching at straws I think 

[blossom60]

Chi Chi - do not buy this much hyped stuff! It's not supposed to be promoted on here anyway.

I might have missed something but it does not look much like anything is being promoted, just discussed.  Surely that's allowed??

Otherwise there would not be much point in any of us signing on!!

[GypsyRoseLee]

When I saw Dr Annie she openly sneered at progesterone cream and was scathing about the 'specialists' who peddle it.

[Kate50]

I feel like I've gone back to square one since taking the 7 days of utrogestan!  Am awake now with night sweat which I dont actually usually get?  Been waking every night again. feeling sluggish in the day. Headaches and yesterday felt a little down which I dont get. Can cope with taking it but the effect afterward is troubling. Bit like a bad period I use to have in my 30s.  Oh and binge eating!  Small dosing everyday would seem the right way to go as in the natural cycle I presume the only way for that would be a topical cream and im not sure why this isn't looked into more?  Professor Studd only uses utrogestan I presume because there's nothing else available? Is there not enough money in making those doses smaller? 
I think I tried emerita progest in the early years of peri I don't think it didn't work it was just that it did but it was too much when you werent sure what was going on  so wasnt confident in using it. I think what ever progesterone you take if you randomly having it for a few days its gonna mess you up as your cycle want like that?
Just some thoughts at 4 in the morning!

[Chi chi]

Kate50 I totally understand what your saying, this is exactly what happens to me! This is what I meant by taking enough to just keep things balanced.
You read so much about how complex hormones are and how it's so important that they're all balanced but what if like us your intolerant to it? What then? 
I also think that taking a tiny amount a day may be better than one big hit, it's much more of a shock to the system! But I suppose a tiny amount a day wouldn't be enough for it to shed the lining?
I'm nearly 2 years into HRT and I'm still none the wiser about it all 

I actually slept better last night than I have done in the last few days, but this morning looks like I'm starting to bleed again  I thought it had stopped finally after 4 weeks!

Can you get any rest today? Hope you're not feeling too lousy x

[Kate50]

Yeah chi chi I don't work.  Just got up actually. I think you could have smaller amounts that's what they do with the combined hrt surely?  Isnt It Just cos utrogestan really licensed for other uses?
I don't feel like im so much intolerant to it just the amount and way its given.
Surely if Studd had found it available in smaller doses wouldn't he be advocating that? ?

[Hurdity]

Just to clarify you can't compare the doses of synthetic progestogens (in combined HRT) with progesterone itself! Firstly they are synthetic and many are  much more powerful than progesterone in keeping the lining thin, which is why they are used (ie have greater affinity for the progesterone receptors I understand). Also progesterone as a molecule is very unstable in the body so we need to take large doses in order for enough to get through the system and into the womb. There have been studies which quantify this ie doses needed to prevent endometrial hyperplasia (which can lead to cancer) which is why the recommended doses are as they are. I do agree that they are overkill in some cases eg the one size fits all dose, even to oppose small doses of oestrogen - so a 50 mg dose would be good. However there isn't really another way unless annual scans are provided on NHS which is unlikely in the current climate! The ovary pumps out small amounts of progesterone but on a continuous basis and the body is designed to function like this. Adding progesterone vaginally or orally is a crude approximation of replicating this, and needs to be sufficient to do the job that the ovary does perfectly well by itself. Synthetic progestogens last much longer in the body so can be taken in smaller doses.

Hurdity x

[Kate50]

Thanks for that info Hurdity.  Women still being treated crudely in the 21st century eh? But on the subject of scans I have had no problem getting one.  Got one on the 11th at my docs from a mobile unit. My doc didn't think there was a problem in having one. I asked as not had any progesterone since starting hrt last September . Studd didn't seem bothered but I wanted to get checked plus only had 3 light days of bleeding after taking utrogestan.