Hi Smokey, I've now upped my mirtrazipine from 15 to 30 after a horrible couple of weeks but like Lisa b had these strange feelings before ads and still do and some.....with you docdog, today my brain feels shivering after an awful night....period started and very very low mood last night, been crying most of the morning....trying to relax on the couch today and not tax my brain mentally, felt like my brain had shattered last night and felt extremely low....taking it easy today maybe a walk in nature.....so guess I'm saying it may be nothing to do with Ms or ad .....have a better day xxx