Hi Kate, I'm sure some of the more knowledgeable ladies will be along to help.
But I can only speak from my experience.
I've been on HRT since December and started in one pump oestrogel alongside mirena coil for the progestogen.
I was advised to try two pumps in January, which I did, within a week I felt awful, jittery, yet lethargic, withdrawn and mood swings, and anxiety.
I persevered for another two weeks with little improvement, so have now reduced to one pump again, feeling much better. I definitely think I'm sensitive to oestrogen.
Hope you get sorted on a regime that works for you xx