Thank you for the replies, I only had the one pack of vagifem, it was 24 tablets in the applicators, I was on a high dose HRT for several years before that, and that's what caused the thickening, had ultra sound in hospital clinic where they checked the thickness, it was just under 7mm.. tried to do a biopsy but couldn't because of the tilted uterus, and told me to go "cold turkey" for 2 months then go back for another ultrasound, if the lining had thinned down, it was obvious the HRT was the cause, so no more of that... and then they'd forget the biopsy which would then have had to be under general anesthetic. Turned out to have gone back to 4mm... end of prob. Vagifem being local for the shortest time should have had no effect. They also said no moisuriser of any sort for at least 10 days before the smear, and they are even told not to use jelly, but just water to lubricate the speculum.... Same nurse did it last time...