Hi lila
I know we have talked before about your situation and trying to find the right HRT and I am sorry to hear you are still feeling rough.
What I'm going to say is controversial to some extent and I'm coming at it from a different angle than babyjane - but I believe it is no coincidence that mostly women are diagnosed with conditions whose symptoms include a lot of fatigue, aches and pains, anxiety, low mood, depression - leading up to and after the menopause. These conditions are fibromyalgia, ME and CFS which share a lot of symptoms. Women on here have been given the diagnosis (or it has been suggested) when in fact the symptoms have been due to a hormone imbalance - which include hypothyroid, menopause - oestrogen deficiency, and testosterone deficiency (which is not tested). I myself was going to be referred for possilbe fibromyalgia by my GP because of my symptoms. Some women are so much more sensitive to changes and deficiencies in these hormones - even when they are within normal range - if indeed they are actually tested.
One woman on here was referred for one of these conditions and reported that the gynae refused to diagnose her on the basis that she was experiencing and suffering these unpleasant symptoms (rather than having a medical disease) - and put her on hormone treatment and her symptoms improved.
I am in no way wishing to minimise the suffering endured by women who have been diagnosed with these conditions, but that the medical profession could do more to find out the real cause - rather than condemning a woman to a life of pain, exhaustion etc with very little help - apart from painkillers and anti-depressants. It may not be the answer for everyone but it might help a huge number of women, and then the medical profession can concentrate on finding out the cause for those women/people for whom a hormone solution is not the answer.
Re your situation - I wonder how many of your symptoms are due to your homone imbalance and early menopause, and maybe not having the right type/dose of HRT from the start, as you were so young? I see that Nuvelle is still available but on continuous combined basis - did you take yours on a cycle? My view would be that you should feel better with the right dose/type of HRT - which means some form of estradiol ( perhpas try a transdermal one if you haven't already) together with progesterone (Utrogestan). I would do this on a cyclical basis until you found the right progestogen that you could tolerate - or even permanently stay on a cycle. Taking them separately would enable you to take a higher dose of oestrogen if necessary rather than a combi product.
Alternatively as you are young, some women are trying/have tried the birth control pill Qlaira which has the bio-identical (body identical) estradiol in it, but about half the month you also take high doses of a synthetic progestogen but crucially not all the time. Continuous synthetic progestogens such as you are taking can have negative side effects for many women and if you have been taking them for years - this could have contributed to some of your problems. I am sure I would end up depressed/with permanent low mood if I took progestogens all the time.
Also babyjane mentioned thyroid - and again this starts to play up for many women and can gives rise to the symptoms of fibromyalgia syndrome (thyroid UK discuss this on their website) - even for some people who are in the normal range. Have you had this tested?
Also testosterone deficiency - I know this is not tested but in your case with early menopause - could you ask for a referral to a menopause clinic?
If it were me I would resist as long as possible a diagnosis of depression in your situation (and associated medication) until you were absolutely sure you were taking the most effective hormone preparation.
This probably isn't what you wanted to hear, but did ask the question in your title and I presume you were looking for thoughts from all angles?
Do have a look at Prof Studd's website and especially what he says about hormones and depression.
http://www.studd.co.uk/ . There are tabs down the left and then sub tabs appear on the right.
I hope this is helpful even if it does not explain your situation
Hurdity x