Hi dap5645,
The oestrogen component of Premique has been around since 1942 so has a wealth of long term studies associated with it. Premique Low Dose (Conjugated Equine Oestrogen plus Medroxyprogesterone Acetate (MPA)) was launched in 2005. The progestogen (MPA) has been well tried and tested too.
As with all medications, there are positives and negatives. You have only been on for 3 weeks so it is early days and will take some time to settle down. I was on Prempak for a while (related product) and it did make me feel yucky after the first pack... everyone is different. I stopped it last May and didn't restart HRT till February this year when I decided to give low dose patches a go. Again I felt yucky to start with but after the first 6 weeks it got better to the point I am better on it than off it.
It really is a matter of trial to see which one suits you best. Try taking it at night before you go to bed so you sleep through the settling in side-effects.
I hope this helps.
Galadriel x