Hurdity - your comment about the beneficial effects of oestrogen being reduced by continuous progesterone strikes a chord with me - I've just stopped continuous utrogestan for an experimental fortnight but kept on with the 50mcg Evorel to see how I feel and the answer is much better mood, energy and sleep. It makes sense that if the progesterone acts in a "feedback" way then the level of oestrogen will drop continuously if progesterone is also taken continuously, doesn't it? - with all the attendant symptoms of low oestrogen. Maybe the best approach is either that of Diana, described earlier, unless the woman concerned is affected by oestrogen dominance/overload, or the traditional 2 weeks on/2 weeks off progesterone mimicking the natural cycle... I suspect GPs are learning about this as they go along just as we are.