Hi Liverpool Lass
from me too.
As the others have said Prempack would not be on the market if it was inherently dangerous. However all the studies which provide the risk data about HRT and the current warnings, limitations of duration of use etc are based on the big Women's Health Initiative Study - which was carred out using conjugated equine oestrogens (as in Prempack) and a synthetic progestogen (different type to the one Prempak I think). Although the design of this study was shown to be flawed, and the absolute risks are very small, later research demonstrates that so far that these same risks don't seem to be there or so apparent using bio-identical/transdermal hormones, and most gynaecologists now recommend transdermal oestrogens (estradiol as patch or gel) and progesterone (if possible) especially for older women and those who are a long time since menopause or who want to use it for a long time.
If you are only just starting menopause and nowhere near 60 then I wouldn't worry at all at the moment - but if you want to stay on it for a long time, and docs try to suggest you stop - then would be the time to think about changing to a different type.
As the others have said - many women do very well on it! How old are you and where abouts in menopause?
Hope you continue to feel better
Hurdity x