I remember being really miffed that I'd noticed no difference after three weeks, until some members said they'd waited over three months (and up to six for the 'full benefit'). I guess it just depends on our individual situations/bodies. I'm on week 5-6 now and can definitely feel psychological improvements, though physical symptoms are still there. My GP wants me to persevere for a minimum of three months, after which time I may swap to Qlaira (she thinks I need something that will over-ride my own cycle). x