Hi all I'm fairly new here, have tried fem conti and Tiblone which both made me very depressed as I ha always had a problem with progesterone. Went to see a private gyne and he said try Tridestra, as usual felt good for a couple if days and now feel awful again, migraines, swelling and generally feeling down, I've gone part time in my job as I just couldn't cope anymore. Wondering if anyone else had tried Tridestra and how long it takes to settle down.