"Vitamin B-6 (pyridoxine) has been reported to cause temporary neurological symptoms such as heaviness, tingling or numbness of the limbs in persons taking very large doses. It is very important to realize that such cases are not common, and when they do occur usually result from huge doses of pyridoxine TAKEN ALONE. The B-vitamins are a team, and work best as a team. Upsetting the balance by taking a lot of just one is like devoting all your baseball practice time to your pitcher. You might get a lot of strikeouts, but if anybody hits one, you are in trouble. No one player has ever won a World Series by himself, and no single B-vitamin can do the job that the whole "team" can do.
B-6 by itself in doses of 2,000 to 6,000 milligrams daily (that's one thousand to three thousand times the US RDA!) can produce side effects and is therefore way too much to take. Very, very few persons report symptoms on 1,000 mg daily, and only the rarest reports go any lower. When taken with, or as part of, a complete B-complex supplement, B-6 side effects other than a harmless deeper-colored urine are virtually unknown.
Its best taken in a B complex supplement2
Best taken in a B complex supplement Sarahm.
excerpt from
http://www.doctoryourself.com/bvitamins.html