Thanks ladies , its early days for me so I am trying to figure out what exactly is causing me to feel so dreadful. it seems to be right at the end of the combined progesterone phase and 2 days into the new pack of oestrogen only, part of the cycle: so the explanation of " usually the progesterone, and then withdrawal from it that causes any negative symptoms." seems to fit. I guess it will be trial and error. Lets hope the femoston is better, as its a different progesterone. Its good to read all the suggestions and ideas . I have found that ginger tablets for pregnancy help with nausea ,and I make natural yogurt which helps with IBS. best wishes Pminty