For myself I notice that low moods, irritability and tiredness/no energy come while,at the end of the white pills (estr/progesterone) and continue on for about a week, i.e. Also at the start of the estrogen pills. So have concluded that this is because at that time of the cycle both hormones are at their lowest. This is bothering me a bit as I 'loose' a good ten days or so of each month to bad moods and self-pitty kind of thinking. Also, this last month ( my 4th on Femoston) , i did't get a bleed. Will see next month. But all in all, femoston is a very good preparation, and so far works quite well for me!