My sister died of secondary bone cancer age 50 (breast cancer age 45). I have been told by several medics that having just one close relative ( parent or sibling ) does not mean you are at more risk than anyone else, but two points to genetics. I doubt a grandmother would be considered a risk. I am 60 and have only started HRT this year. There is the over 60s debate going on and many doctors are reluctant to prescribe, but I am surprised you have been told you can't take HRT at 50. Difficult to advise you as you live in France, other than the usual suggestions of seeing a different doctor/gynaecologist and taking along information from this website. I had to go privately, but do have the support of my GP.