I have just started the Evorel 50 patches, two a week. I have the Mirena fitted too. I was diagnosed through my symptoms as peri menopause I am 43 so it's a little early. I started the patches two weeks ago because of out of character low mood and pms symptoms. For the past week I have been feeling an off and on a mild burning sensation around where my left ovary should be which is something I have not felt before. It comes and goes all day. Do you have any advice... Could this be side effect of the estrogen that should settle down. I do not see my doctor again for 6 weeks to discuss how I feel taking the estrogen. I can go back any time but do not want to unless necessary.