Hi there & welcome.
I'm only on oestrogen, no antidepressants. Others on here can give you some advice on that. However, when I took an HRT break 4 years ago I used to get horrid feeling prior to a flush. Wouldn't call it a mood change as such, more a weird tingling coming up from my feet for about a minute prior to flush.
I'm trying to come HRT since beginning of this year, odd flush but not too bad. But this time last year I tried to come off it, but had to up the dose again. Meno consultant said my body wasn't ready for coming off it.
Can you get a referral to a meno clinic at all or even a gynae referral?