oh crumb, I started writing a reply and touched some magic key and it's gone, well thank you again Hurdity, very helpful, I am 46 and started transdermal bioidentical progesterone about 10 years ago with 25mg. That helped tremendously with everything, esp the nausea. The anxiety started 2 years ago, never had it before and it started with small challenges like being able to sit through a whole movie at the theatre. I increased the cream on the advice of a naturopathic doctor to 60 mgs in the fall 2013, but I don't think it helped much. The anxiety was worse and getting weird, like not wanting to drive in the dark and I love to drive. The anxiety seems to worse around ovulation. My periods are kind of regular, normally are 21(all my life sigh) days but this year I have had cycles of 14, 37, 25 days, but usually 21 or 22 days for most of the year. In Dec I went to my GP who has never supported the bioidentical progesterone and told her the anxiety was starting to interfere with daily living. She said either Mirena or low dose contraceptive would help. I went for the contraceptive pill and stopped the cream and I have been bleeding slightly now for two weeks. I am waiting to see if the anxiety eases up. I feel a bit lost right now and will go back to ask about the estradiol. Also maybe it is time to try another delivery method rather than transdermal if I go back to the natural progesterone. Sounds like I don't know what I want! thanks for the advice, I wish we had menopausal clinics here or support groups. I have a lovely counsellor who got me through the pain and trauma of a car accident 7 years ago, so I think it is time to ask for help with this issue. I am off to check john s and Elizabeth v - thanks again, one positive of this experience is that I have developed much empathy for others with anxiety, it isn't just a word anymore.