Hi roseclimber
1 dose (full applicator) of gynest cream and 1 orthogynest pessary each deliver 0.5 mg estriol so they are exactly the same in that respect.
However it may be that the cream leaks out more easily whereas the pessaries are waxy and maybe stay in position a bit better? Hence the difference. I use the pessaries, but when stocks evetually run out will have to use the cream (and the inconvenient applicator!) or Vagifem
Hurdity x