Ovestin cream is much stronger than Gynest cream, and from what I gather has a smaller applicator and each dose contains a tiny amount of cream (0.5 g). I haven't ever used this. Are you following the instructions carefully? If you vary the amount then there is greater margin for error with a more concentrated compound normally measured in small doses, so maybe greater potential for more than 0.5 g so perhaps more side effects - if you are going to experience them? Thinkiing aloud here!
I have read that estriol is a weaker oestrogen than estradiol in terms of binding to oestrogen receptors so that any that is absorbed systemically (eg in the first two weeks) is likely to have a lesser effect than estradiol - but I don't really understand the bio-chemistry of all of this as it is complex!!
I presume you are re-doing the 2 week loading?
From what I remember they were stopping the manufacture (which is who I phoned) at thecompnay ( J-J - can't remember the name!) so nothing to do with NHS - but a commercial decision from the company. My GP isn't pleased because it is the best estriol preparation - no messy creams to deal with...
Hurdity x