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HRT preparations: Estrogens


Please note: Patients should consult a health professional to decide on the appropriate treatment option to be prescribed.

The products marked * are licensed for prevention and/or treatment of osteoporosis.

TABLET

a. Low dose - recommended starting dose.

ELLESTE SOLO 1mg estradiol £1.69
PROGYNOVA 1mg estradiol valerate £2.43
PREMARIN 0.3mg conjugated estrogens £2.02
ZUMENON 1mg estradiol £2.30

b. Medium dose

BEDOL 2mg estradiol £1.69
ELLESTE SOLO* 2mg estradiol £1.69
PREMARIN* 0.625mg conjugated estrogens £1.34
PROGYNOVA* 2mg estradiol valerate £2.43
ZUMENON* 2mg estradiol £2.30

c. Higher dose - when symptoms are not controlled by the above.

PREMARIN* 1.25mg conjugated estrogens £1.19

NON-TABLET

a. Patches - can be matrix (M) or reservoir (R) Matrix tend to cause less skin irritation and adhere better. Patches can be changed once or twice weekly.

Low dose

Estraderm MX 2 x wkly M 25 mcg estradiol / 24hrs. £5.50
Estradot 2 x wkly M 25 mcg estradiol / 24hrs £5.99
Estradot 2 x wkly M 37.5 mcg estradiol / 24hrs £6.00
Evorel 2 x wkly M 25 mcg estradiol / 24hrs. £3.42

Medium dose

Elleste Solo MX 2 x wkly M 40 mcg estradiol / 24hrs. £5.19
Estraderm MX 2 x wkly M 50 mcg estradiol / 24hrs.* £5.51
Estradot 2 x wkly M 50 mcg estradiol / 24hrs.* £6.02
Evorel 2 x wkly M 50 mcg estradiol / 24hrs.* £3.88
FemSeven 1 x wkly M 50 mcg estradiol / 24hrs.* £6.04
Progynova TS 1 x wkly M 50 mcg estradiol / 24hrs.* £6.30

High dose

Elleste Solo MX 2 x wkly M 80 mcg estradiol / 24hrs.* £5.99
Estraderm MX 2 x wkly M 75 mcg estradiol / 24hrs. £6.42
Estradot 2 x wkly M 75 mcg estradiol / 24hrs.* £7.00
Evorel 2 x wkly M 75 mcg estradiol / 24hrs.* £4.12
FemSeven 1 x wkly M 75 mcg estradiol / 24hrs.* £6.98

Higher dose

Estraderm MX 2 x wkly M 100 mcg estradiol / 24hrs. £6.66
Estradot 2 x wkly M 100 mcg estradiol / 24hrs.* £7.27
Evorel 2 x wkly M 100 mcg estradiol / 24hrs.* £4.28
FemSeven 1 x wkly M 100 mcg estradiol / 24hrs.* £7.28
Progynova TS 1 x wkly M 100 mcg estradiol / 24hrs.* £6.90

b. Gels - are useful if transdermal treatment is the option preferred but skin irritation occurs with patches.

OESTROGEL 2* measures once daily (1.5mg estradiol) increased if necessary to max 4 daily (3.0mg estradiol) £4.20 for
64-dose pump
SANDRENA 1 application daily 0.5mg or 1mg -dose range 0.5 to 1.5mg daily. £5.08 & £5.85

c. Implants - usually used as a last resort in patients post-hysterectomy when symptoms are not controlled by other means.

ESTRADIOL IMPLANT 25, 50 or 100 mg 6 monthly -recommended is 25 or 50mg implant.  

All estrogen only preparations can be used in patients who have not had a hysterectomy, as long as an appropriate progestogen is given in addition.
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Page last updated: 5 December 2013

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